Dopamine Receptor


Image Caption : Dopamine Receptor : Dopamine is a neurotransmitter that is central to the brain network governing motivation, the sense of reward, and feelings of pleasure. Alterations to the dopaminergic system affect how people act on the inherent desire to seek out pleasure and avoid pain. It can be thought of as a biological cheerleader that tells a person to keep doing one thing, or stop doing another. Dopamine also helps regulate many of the systems of the body, including the kidneys and the heart.

Dopamine

Dopamine-mainly involved in controlling movement and aiding the flow of information to the front of the brain, which is linked to thought and emotion. It is also linked to reward systems in the brain. Problems in producing dopamine can result in Parkinson's disease, a disorder that affects a person's ability to move as they want to, resulting in stiffness, tremors or shaking, and other symptoms. Some studies suggest that having too little dopamine or problems using dopamine in the thinking and feeling regions of the brain may play a role in disorders like schizophrenia or attention deficit hyperactivity disorder (ADHD).

The National Institute of Mental Health (NIMH) / (NIH)

Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors.

Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors.


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