Dopamine Receptor : Dopamine is a neurotransmitter that is central to the brain network governing motivation, the sense of reward, and feelings of pleasure. Alterations to the dopaminergic system affect how people act on the inherent desire to seek out pleasure and avoid pain. It can be thought of as a biological cheerleader that tells a person to keep doing one thing, or stop doing another. Dopamine also helps regulate many of the systems of the body, including the kidneys and the heart.
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors.
Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors.
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