Aldosterone & Renin

Aldosterone & Renin

Other names: Aldosterone and plasma renin activity, PRA (plasma renin activity)
Specimen: Aldosterone: Blood or Urine, Renin: Blood



Your Aldosterone & Renin is

Normal aldosterone (adult male, upright, 4:00pm-6:00pm): less than or equal to 21 ng/dL
\r\nNormal PRA (plasma renin activity): 0.25-5.82 ng/mL/h
\r\nNormal aldosterone/PRA ratio: 0.9:28.9

Aldosterone is a hormone produced in the adrenal glands that helps control blood pressure, in part by maintaining sodium and potassium levels. When blood pressure drops or abnormal levels of sodium and potassium are in circulation, the kidneys release renin. Renin is an enzyme that promotes the production of angiotensin, which is also important in controlling blood pressure. Tested together, with results read as a ratio, aldosterone and renin levels are dual indicators of:
  • Primary hyperaldosteronism (high aldosterone, low renin)
  • Secondary hyperaldosteronism (high aldosterone, high renin)
  • Adrenal insufficiency (low aldosterone, high renin)
Aldosterone and renin are tested together to determine whether the body's production of the hormone aldosterone is excessive or deficient and to distinguish potential causes of an imbalance. Overproduction indicates primary hyperaldosteronism, or Conn syndrome, which causes hypertension. Primary hyperaldosteronism is due to overproductive adrenal glands, usually resulting from a benign tumor in one of the glands. Aldosterone/renin testing is most useful in screening for this condition. Secondary hyperaldosteronism is more common and may occur due to renal artery stenosis, among other diverse causes. Underproduction of aldosterone is an indication of adrenal insufficiency, or Addison's disease.
Conn syndrome (aka Conn's syndrome) is the most common cause of secondary hypertension, which is a case of high blood pressure resulting from a condition of the kidneys, arteries, heart, or endocrine system (essential hypertension, which is more common, is associated with genetics, poor diet, and lack of exercise). Anyone with such a condition may be at risk. Addison's disease, which can be life-threatening, occurs in both sexes and affects all age groups.